Daily Practice Experience of Baricitinib Treatment for Patients with Difficult-to-Treat Atopic Dermatitis: Results from the BioDay Registry

Authors

  • Celeste M. Boesjes Department of Dermatology and Allergology, University Medical Center Utrecht, Heidelberglaan 100, PO Box 85500, NL-3584 CX Utrecht, The Netherlands https://orcid.org/0000-0002-3371-6414
  • Esmé Kamphuis Department of Dermatology, University Medical Center Groningen, Groningen, The Netherlands https://orcid.org/0000-0002-4265-9634
  • Nicolaas P.A. Zuithoff Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands https://orcid.org/0000-0002-4441-1448
  • Daphne S. Bakker DDepartment of Dermatology and Allergology, University Medical Center Utrecht, Heidelberglaan 100, PO Box 85500, NL-3584 CX Utrecht, The Netherlands https://orcid.org/0000-0002-0193-5794
  • Laura Loman Department of Dermatology, University Medical Center Groningen, Groningen, The Netherlands https://orcid.org/0000-0003-2731-9284
  • Lotte S. Spekhorst Department of Dermatology and Allergology, University Medical Center Utrecht, Heidelberglaan 100, PO Box 85500, NL-3584 CX Utrecht, The Netherlands
  • Inge Haeck Department of Dermatology, Reinier de Graaf Gasthuis, Delft, The Netherlands
  • Marijke Kamsteeg Department of Dermatology, Radboud University Medical Center, Radboud University, The Netherlands https://orcid.org/0000-0002-1389-2971
  • Anneke M.T. van Lynden-van Nes Department of Dermatology, Meander Medical Centrum, Amersfoort, The Netherlands
  • Floor M.Garritsen Department of Dermatology, Haga Hospital, Den Haag, The Netherlands
  • Klaziena Politiek Department of Dermatology, Medical Center Leeuwarden, Leeuwarden, The Netherlands https://orcid.org/0000-0001-6475-6876
  • Marja Oldhoff Department of Dermatology, University Medical Center Groningen, Groningen, The Netherlands https://orcid.org/0000-0001-5578-5325
  • Marlies de Graaf Department of Dermatology and Allergology, University Medical Center Utrecht, Heidelberglaan 100, PO Box 85500, NL-3584 CX Utrecht, The Netherlands https://orcid.org/0000-0001-9004-5111
  • Marie L.A. Schuttelaar Department of Dermatology, University Medical Center Groningen, Groningen, The Netherlands https://orcid.org/0000-0002-0766-4382
  • Marjolein S. de Bruin-Weller Department of Dermatology and Allergology, University Medical Center Utrecht, Heidelberglaan 100, PO Box 85500, NL-3584 CX Utrecht, The Netherlands https://orcid.org/0000-0002-1249-6993

DOI:

https://doi.org/10.2340/actadv.v102.3978

Keywords:

atopic dermatitis, baricitinib, daily practice, JAK-inhibitor, PROMs

Abstract

Clinical trials have shown that baricitinib, an oral selective Janus kinase 1/2 inhibitor, is effective for the treatment of moderate-to-severe atopic dermatitis. However, daily practice data are limited. Therefore, this multicentre prospective study evaluated the effectiveness and safety of 16-weeks’ treatment with baricitinib in adult patients with moderate-to-severe atopic dermatitis in daily practice. A total of 51 patients from the BioDay registry treated with baricitinib were included and evaluated at baseline and after 4, 8 and 16 weeks of treatment. Effectiveness was assessed using clinician- and patient-reported outcome measurements. Adverse events and laboratory assessments were evaluated at every visit. At week 16, the probability (95% confidence interval) of achieving Eczema Area and Severity Index ≤ 7 and numerical rating scale pruritus ≤ 4 was 29.4% (13.1–53.5) and 20.5% (8.8–40.9), respectively. No significant difference in effectiveness was found between dupilumab non-responders and responders. Twenty-two (43.2%) patients discontinued baricitinib treatment due to ineffectiveness, adverse events or both (31.4%, 9.8% and 2.0%, respectively). Most frequently reported adverse events were nausea (n = 6, 11.8%), urinary tract infection (n = 5, 9.8%) and herpes simplex infection (n = 4, 7.8%). In conclusion, baricitinib can be an effective treatment option for moderate-to-severe atopic dermatitis, including patients with non-responsiveness on dupilumab. However, effectiveness of baricitinib is heterogeneous, which is reflected by the high discontinuation rate in this difficult-to-treat cohort. 

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Published

2022-11-24

How to Cite

Boesjes, C. M., Kamphuis, E., Zuithoff, N. P., Bakker, D. S. ., Loman, L. ., Spekhorst, L. S. ., Haeck, I., Kamsteeg, M. ., van Lynden-van Nes, A. M., Garritsen, F. M. ., Politiek, K., Oldhoff, M. ., de Graaf, M., Schuttelaar , M. L. ., & de Bruin-Weller, M. S. . (2022). Daily Practice Experience of Baricitinib Treatment for Patients with Difficult-to-Treat Atopic Dermatitis: Results from the BioDay Registry. Acta Dermato-Venereologica, 102, adv00820. https://doi.org/10.2340/actadv.v102.3978

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