Establishment and Utility of SwedAD: A Nationwide Swedish Registry for Patients with Atopic Dermatitis Receiving Systemic Pharmacotherapy

Authors

  • Mikael Alsterholm Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
  • Axel Svedbom Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
  • Chris D. Anderson Department of Dermatology and Venereology, County Council of Östergötland, Linköping, Sweden
  • Lena Holm Sommar Stockholm Hud, Stockholm, Sweden
  • Lina U. Ivert Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
  • Anna Josefson School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
  • Laura von Kobyletzki School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
  • Magnus Lindberg School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
  • Lena Lundeberg Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
  • Maria Lundqvist Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
  • Elisabet Nylander Department of Public Health and Clinical Medicine, Dermatology and Venereology, Umeå University, Umeå, Sweden
  • MariHelen Sandström Falk Capio Skin, Carlanderska Hospital, Gothenburg, Sweden
  • Alexander Shayesteh Department of Public Health and Clinical Medicine, Dermatology and Venereology, Umeå University, Umeå, Sweden
  • Gunnthorunn Sigurdardottir Department of Dermatology and Venereology, County Council of Östergötland, Linköping, Sweden
  • Andreas Sonesson Department of Dermatology and Venereology, Skåne University Hospital, Lund, Sweden
  • Åke Svensson Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden
  • Marie Virtanen Department of Medical Sciences, Section of Dermatology, Uppsala University, Uppsala, Sweden
  • Sophie Vrang Patients’ organization Atopikerna, The Swedish Asthma and Allergy Association, Stockholm, Sweden
  • Carl-Fredrik Wahlgren Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
  • Maria Bradley Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
  • Emma K. Johansson Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

DOI:

https://doi.org/10.2340/actadv.v103.7312

Keywords:

Dupilumab, Janus Kinase Inhibitors, Methotrexate, Real-world data, Registries

Abstract

SwedAD, a Swedish nationwide registry for patients with atopic dermatitis receiving systemic pharmacotherapy, was launched on 1 September 2019. We describe here the establishment of a user-friendly registry to the benefit of patients with atopic dermatitis. By 5 November 2022, 38 clinics had recorded 931 treatment episodes in 850 patients with an approximate national coverage rate of 40%. Characteristics at enrolment included median Eczema Area and Severity Index (EASI) 10.2 (interquartile range 4.0, 19.4), Patient-Oriented Eczema Measure (POEM) 18.0 (10.0, 24.0), Dermatology Life Quality Index (DLQI) 11.0 (5.0, 19.0) and Peak Itch Numerical Rating Scale-11 (NRS-11) 6.0 (3.0, 8.0). At 3 months, median EASI was 3.2 (1.0, 7.3) and POEM, DLQI, and NRS-11 were improved. Regional coverage varied, reflecting the distribution of dermatologists, the ratio of public to private healthcare, and difficulties in recruiting certain clinics. This study highlights the importance of a nationwide registry when managing systemic pharmacotherapy of atopic dermatitis. 

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Published

2023-04-06

How to Cite

Alsterholm, M., Svedbom, A. ., Anderson, C. D., Holm Sommar, L., Ivert, L. U., Josefson, A., … Johansson, E. K. (2023). Establishment and Utility of SwedAD: A Nationwide Swedish Registry for Patients with Atopic Dermatitis Receiving Systemic Pharmacotherapy. Acta Dermato-Venereologica, 103, adv7312. https://doi.org/10.2340/actadv.v103.7312

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