Physician-reported Clinical Unmet Needs, Burden and Treatment Patterns of Paediatric Psoriasis Patients: A US and EU Real-world Evidence Study

Authors

  • Marieke M.B. Seyger Department of Dermatology, Radboud University Nijmegen Medical Centre, NL-6500 HB Nijmegen, the Netherlands
  • Matthias Augustin
  • Michael Sticherling
  • Teresa Bachhuber
  • Juanzhi Fang
  • James Hetherington
  • James Lucas
  • Sophie Meakin
  • Craig Richardson
  • Amy S. Paller

DOI:

https://doi.org/10.2340/actadv.v101.981

Keywords:

psoriasis, paediatric psoriasis, point-in-time survey, real-world, clinical characteristics, unmet needs

Abstract

This study is a retrospective analysis using data collected from the Adelphi Paediatric Psoriasis Disease-Specific Programme cross-sectional survey. Despite being treated for their psoriasis, a substantial proportion of paediatric patients presented with moderate (18.3%) or severe (1.3%) disease at sampling; 42.9% and 92.0% had a body surface area (BSA) of >10%, and 38.8% and 100.0% had a Psoriasis Area Severity Index (PASI) score >10, respectively. Overall, 69.9% of patients had only ever been treated with a topical therapy for their psoriasis. For patients with moderate or severe disease at sampling, 16.3% and 14.4% were currently receiving conventional systemics or biologic therapy, respectively. There is a clinical unmet need in this paediatric population; a considerable percentage of patients still experienced moderate or severe disease and persistent psoriasis symptoms, with numerous body areas affected. A significant proportion of patients were undertreated, which may explain the high burden of disease observed.

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Published

2022-02-28

How to Cite

Seyger, M. M., Augustin, M., Sticherling, M., Bachhuber, T., Fang, J., Hetherington, J., Lucas, J., Meakin, S., Richardson, C., & Paller, A. S. (2022). Physician-reported Clinical Unmet Needs, Burden and Treatment Patterns of Paediatric Psoriasis Patients: A US and EU Real-world Evidence Study. Acta Dermato-Venereologica, 102, adv00660. https://doi.org/10.2340/actadv.v101.981